Targeting the microenvironment of pancreatic cancer: overcoming treatment barriers and improving local immune responses
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چکیده
منابع مشابه
Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment.
It is widely recognized that the vasculature of the tumor is inadequate to meet the demands of the growing mass. The malformed vasculature is at least in part responsible for regions of the tumor that are hypoxic, acidotic, and exposed to increased interstitial fluid pressure. These unique aspects of the tumor microenvironment have been shown to act as barriers to conventional chemotherapy or r...
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ژورنال
عنوان ژورنال: Clinical and Translational Oncology
سال: 2015
ISSN: 1699-048X,1699-3055
DOI: 10.1007/s12094-015-1459-8